Analytical Data
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基因名
PON2
- Application
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别名
PON2；Serum paraoxonase/arylesterase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15165
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表达区间
1-354aa
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氨基酸序列
MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL YCEL
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PON2 (paraoxonase 2) is a member of the paraoxonase gene family, which encodes for enzymes involved in the hydrolysis of toxic substances and the metabolism of lipids. Research on PON2 has gained attention due to its potential roles in cardiovascular disease, oxidative stress, and neurodegenerative disorders. Unlike its counterparts, PON1 and PON3, PON2 exhibits a more ubiquitous expression pattern and is localized primarily within cells, particularly in the mitochondria. This positioning suggests that PON2 may play a significant role in cellular defense mechanisms against oxidative damage. Studies have demonstrated that PON2 can modulate inflammatory responses and protect cells from apoptosis. Furthermore, its antioxidant properties and involvement in lipid metabolism make it a candidate for protective strategies against atherosclerosis and other metabolic syndromes. The recombinant expression of PON2 has enabled researchers to investigate its biochemical properties further, including enzyme kinetics and the molecular basis for its protective effects. Understanding PON2's structure-function relationship and its interactions with various substrates could lead to novel therapeutic approaches for diseases associated with oxidative stress and inflammation, highlighting its importance in biomedical research.
