Analytical Data
-
Gene name
ZDHHC6
- Application
-
Alternative Names
ZDHHC6; ZNF376; Palmitoyltransferase ZDHHC6; Stearoyltransferase ZDHHC6; Transmembrane Protein H4; Zinc finger DHHC domain-containing Protein 6; DHHC-6; Zinc finger Protein 376
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9H6R6
-
Expression Region
1-409 aa
-
AA Sequence
MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR
-
Molecular Weight
70.73 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZDHHC6, a member of the palmitoyltransferase family, plays a crucial role in post-translational modifications by adding palmitate groups to protein substrates, which impacts their membrane localization, stability, and interaction with other cellular components. The dysregulation of ZDHHC6 has been associated with various diseases, including neurodegenerative disorders and cancer, highlighting its potential as a therapeutic target. Research has focused on understanding the enzyme's substrate specificity, molecular mechanisms, and physiological functions in cellular signaling pathways. As a result, recombinant ZDHHC6 protein production has become integral to studying its biochemical properties and functional roles in native biological contexts. The availability of ZDHHC6 in a purified form allows for in-depth exploration of its interactions with specific target proteins, the influence of palmitoylation on protein behavior, and the broader implications for cellular homeostasis and disease pathology. Consequently, advancements in recombinant protein technology have paved the way for novel insights into the significance of ZDHHC6 in health and disease, fostering the development of targeted interventions.
