Analytical Data
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Gene name
ZDHHC11
- Application
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Alternative Names
ZDHHC11; ZNF399; Palmitoyltransferase ZDHHC11; Zinc finger DHHC domain-containing Protein 11; DHHC-11; Zinc finger Protein 399
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H8X9
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Expression Region
1-412 aa
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AA Sequence
MDTRSGSQCSVTPEAILNNEKLVLPPRISRVNGWSLPLHYFQVVTWAVFVGLSSATFGIFIPFLPHAWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRLMKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINNCVGSRNYWFFFSTVASATAGMLCLIAILLYVLVQYLVNPGVLRTDPRYEDVKNMNTWLLFLPLFPVQVQTLIVVIIGMLVLLLDFLGLVHLGQLLIFHIYLKAKKMTTFEYLINNRKEESSKHQAVRKDPYVQMDKGVLQQGAGALGSSAQGVKAKSSLLIHKHLCHFCTSVNQDGDSTAREGDEDPCPSALGAKARNSRLICRRLCQFSTRVHPDGGSMAQEADDAPSISTLGLQQETTEPMKTDSAESED
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Molecular Weight
72.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZDHHC11, a member of the ZDHHC (zinc finger DHHC-type containing) family, is known for its role as a palmitoyl transferase, which facilitates the attachment of palmitic acid to cysteine residues on target proteins. This post-translational modification is crucial for regulating protein trafficking, stability, and interactions, thereby influencing various cellular processes. Research on ZDHHC11 has gained significance due to its potential implications in neurodevelopmental disorders and other diseases. Mutations or dysregulation of ZDHHC family members have been linked to conditions such as autism and schizophrenia, highlighting the need to understand their functional mechanisms better. The interest in ZDHHC11 also stems from its unique substrate specificity and its contribution to the palmitoylation landscape, which can affect signal transduction pathways. Therefore, studies involving the recombinant expression of ZDHHC11 protein can provide insights into its enzymatic activity, substrate interactions, and regulatory mechanisms, paving the way for novel therapeutic strategies targeting palmitoylation processes in various pathological states.
