Analytical Data
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Gene name
CRHR1
- Application
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Alternative Names
CRHR1；CRFR；CRFR1；CRHR；Corticotropin-releasing factor receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P34998-2
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Expression Region
1-415aa
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AA Sequence
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDL IGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYS ECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCL RNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHV TNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGK LYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSF LESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTS PTRVSFHSIKQSTAV
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Molecular Weight
74 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRHR1 (Corticotropin-Releasing Hormone Receptor 1) is a critical component of the hypothalamic-pituitary-adrenal (HPA) axis, playing a pivotal role in regulating stress responses and maintaining homeostasis. This receptor is activated by corticotropin-releasing hormone (CRH), which triggers a cascade of physiological events that influence mood, anxiety, and behavior. Dysregulation of CRHR1 has been implicated in various neuropsychiatric disorders, including depression, anxiety, and post-traumatic stress disorder (PTSD). Given its central role in stress-related pathways, CRHR1 has emerged as a promising target for therapeutic intervention. Researchers have focused on characterizing the receptor's structure, function, and downstream signaling mechanisms. The development of recombinant CRHR1 proteins has allowed for more detailed studies of ligand-receptor interactions and the effects of various pharmacological agents. Additionally, understanding the receptor's role in different cell types and its potential genetic polymorphisms contributes to insights into individual variability in stress responses and susceptibility to mental health disorders. As such, CRHR1 remains an active area of investigation in both basic and clinical research, with the aim of uncovering novel strategies for the treatment of stress-related conditions.
