Analytical Data
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基因名
FMR1
- Application
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别名
FMR1；Fragile X messenger ribonucleoProtein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IXW7
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表达区间
1-297aa
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氨基酸序列
MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFP PPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACD ATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDF KKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIM RNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGV TAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGLKI
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分子量
58 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FMR1, or Fragile X Mental Retardation 1, is a critical gene located on the X chromosome, and its expanded CGG repeat sequence is linked to Fragile X Syndrome, the most common inherited form of intellectual disability. The protein produced by the FMR1 gene, known as FMRP (Fragile X Mental Retardation Protein), plays a significant role in neuronal function and synaptic plasticity by regulating the translation of specific mRNAs at synapses. Research on FMR1 recombinant proteins has gained momentum as scientists seek to understand the molecular mechanisms underlying its involvement in neural signaling and its association with cognitive deficits. In various models, including cellular and animal models, FMRP's function in RNA binding and regulation has been explored, advancing our knowledge of how its absence leads to the cognitive impairments seen in Fragile X Syndrome. Additionally, FMR1 research has broad implications, as it contributes not only to our understanding of Fragile X but also offers insights into related neurodevelopmental disorders. The exploration of FMR1 recombinant proteins aids in developing potential therapeutic strategies aimed at mitigating the symptoms associated with Fragile X Syndrome, highlighting the importance of continued investigation in this field.
