Analytical Data
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Gene name
ZCCHC2
- Application
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Alternative Names
9930114B20Rik; AW212015; DKFZp451A185; FLJ20281; KIAA1744; MGC112793; MGC13269; Tnfrsf11a; ZCCHC2; ZCHC2_HUMAN; Zinc finger CCHC domain containing Protein 2; Zinc finger CCHC domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C0B9
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Expression Region
1-362 aa
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AA Sequence
MPGGGGGPSAALREQERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQRVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQVRRTEPPWTRGAIAAPAASPASLSDAPCPSPSPAQVARNPHPAAPSARGLSFVSLGRSVPLPHPTPHPGRHSHPPSQNALEVPSVPRCCHGRRGAPRPGPLSEEKCRDVFGSEHLSARCGSRGALEEPV
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Molecular Weight
65.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZCCHC2 is a gene encoding a zinc finger CCHC-type containing protein, which has garnered research interest due to its potential role in various biological processes, including RNA metabolism, gene regulation, and immune responses. Studies have indicated that ZCCHC2 is implicated in antiviral immune responses, particularly in the context of RNA viral infections, by influencing the host's ability to recognize and respond to viral RNA. Furthermore, aberrations in the expression or function of ZCCHC2 have been associated with certain diseases, including cancers and autoimmune disorders. Understanding the structure and function of ZCCHC2 at a molecular level, particularly through recombinant protein studies, can provide crucial insights into its regulatory mechanisms and biological significance. Researchers have employed various methods to produce ZCCHC2 recombinant protein, enabling the investigation of its interactions with RNA and other cellular components. This knowledge not only sheds light on fundamental biological processes but also holds potential for therapeutic applications, as targeting ZCCHC2-related pathways may offer novel strategies for treating diseases linked to its dysregulation. Overall, the characterization of ZCCHC2 as a recombinant protein represents a promising area of research with implications for both basic biology and clinical advances.
