Analytical Data
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Gene name
EFCAB4B
- Application
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Alternative Names
CRACR2A; EFCAB4B; EF-hand calcium-binding domain-containing protein 4B; Calcium release-activated calcium channel regulator 2A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BSW2
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Expression Region
1-395aa
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AA Sequence
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV
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Molecular Weight
72 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EFCAB4B, or EF-hand calcium-binding protein 4B, is a member of the EFCAB family known for its role in calcium signaling and cellular functions. Understanding EFCAB4B is of particular interest due to its potential involvement in various physiological processes and diseases, including muscle contraction, neuronal signaling, and cell proliferation. Research has indicated that EFCAB4B may play critical roles in regulating intracellular calcium levels, which are essential for numerous signaling pathways. The protein has been linked to the modulation of gene expression and cytoskeletal dynamics, highlighting its importance in maintaining cellular homeostasis. Moreover, alterations in EFCAB4B expression or function have been associated with pathological conditions, including cardiac and neurodegenerative diseases. Investigating the structure and function of EFCAB4B, especially through recombinant protein studies, can provide insights into its mechanisms of action and therapeutic potential. Advanced techniques in molecular biology and biochemistry are often employed to study the protein's binding affinities, structural conformation, and interaction with other cellular partners. Understanding EFCAB4B's role in calcium signaling networks may pave the way for developing novel interventions for diseases linked to calcium dysregulation. Overall, research on EFCAB4B is crucial for elucidating its biological significance and potential implications in health and disease.
