Analytical Data
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Gene name
EFCAB2
- Application
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Alternative Names
EFCAB2; DRC8Dynein regulatory complex protein 8; EF-hand calcium-binding domain-containing protein 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5VUJ9
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Expression Region
1-269aa
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AA Sequence
MLGPGQVRLR PRVWRDKAGG RVADGASGLP PARGSWRETG TGRALGASSP PRPAQGSSSP GIQSGPSSRP GSPRGAEQAG TPRPRLSLGI SQATGSAARW RTRRTGKGLG YNSDEIRPRT LLIEHLMEGG RRDHHTMTVL WGTQEIIVAE FHKKIKEAFE VFDHESNNTV DVREIGTIIR SLGCCPTEGE LHDLIAEVEE EEPTGYIRFE KFLPVMTEIL LERKYRPIPE DVLLRAFEVL DSAKRGFLTK DELIKYMTEE DGVSLRRPG
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Molecular Weight
29.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EFCAB2, or "EFCAB2 protein," is part of the EF-hand calcium-binding protein family, which plays a crucial role in various cellular processes. Understanding EFCAB2 is significant due to its potential involvement in calcium signaling pathways, which are fundamental for cellular functions including muscle contraction, neurotransmitter release, and gene expression. Research has indicated that EFCAB2 may have specific roles in the regulation of calcium-dependent processes, and its dysregulation has been associated with various diseases, including neurodegenerative disorders and certain cancers. The recombinant expression of EFCAB2 protein allows for in-depth studies of its structure and function, enabling researchers to explore its interaction with calcium and other cellular components. Moreover, recombinant EFCAB2 provides a valuable tool for drug discovery and the development of therapeutic interventions targeting calcium homeostasis. By utilizing advanced techniques such as protein purification and structural analysis, scientists aim to elucidate the mechanisms underlying EFCAB2's involvement in health and disease, thereby paving the way for novel therapeutic strategies. As research continues to unfold, EFCAB2 stands out as a significant focus in the field of molecular biology and biochemistry, highlighting the importance of understanding calcium signaling in the maintenance of cellular integrity and function.
