Analytical Data
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Gene name
ECGF1
- Application
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Alternative Names
ECGF 1; ECGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Endothelial cell growth factor. platelet-derived; Gliostatin; hPD ECGF; MEDPS1; MNGIE; MTDPS1; PD ECGF; PD-ECGF; PDECGF; PDEGF
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P19971
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Expression Region
1-482aa
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AA Sequence
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPLPFAELVLPPQQ
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Molecular Weight
76.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ECGF1, or Endothelial Cell Growth Factor 1, is a protein that plays a crucial role in angiogenesis, the process of new blood vessel formation, which is vital for various physiological and pathological conditions, including wound healing, tumor growth, and ischemic diseases. Initial studies into ECGF1 highlighted its potential in promoting endothelial cell proliferation, migration, and survival, making it an important target for therapeutic applications. Researchers have been particularly interested in its reconstitution and expression as a recombinant protein, which enables the detailed study of its functional properties and interactions with other cellular components. The use of recombinant techniques allows scientists to produce ECGF1 in high quantities, facilitating both in vitro and in vivo studies. Ongoing research examines its mechanisms of action, the signaling pathways it influences, and its potential use in clinical settings, such as developing treatments for cancer, cardiovascular diseases, and other conditions where angiogenesis plays a critical role. Understanding ECGF1's role in these processes may lead to novel strategies for manipulating blood vessel growth in therapeutic contexts, providing valuable insights into its application in regenerative medicine and targeted therapies.
