Analytical Data
-
基因名
TCF3
- Application
-
别名
Amida; INO80 complex subunit F; INO80F; Protein FB1; TCF3 (E2A) fusion partner (in childhood Leukemia); TCF3 fusion partner; TFPT; TFPT_HUMAN
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P0C1Z6
-
表达区间
1-253 aa
-
氨基酸序列
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRASQFTIVL EDEGSQGTDA PTPGNAENEP PEKETLSPPR RTPAPPEPGS PAPGEGPSGR KRRRVPRDGR RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK LLPYPTLASP ASD
-
分子量
28.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TCF3, also known as E2A, is a transcription factor that plays a critical role in hematopoiesis and lymphocyte development. Its importance in immunology and cancer biology has led to extensive research into its function and regulatory mechanisms. TCF3 is involved in various physiological processes, including cell proliferation, differentiation, and survival, primarily by regulating gene expression in response to developmental cues. In particular, TCF3 is known to form complexes with other proteins, influencing the transcriptional activity essential for B-cell and T-cell lineages. However, mutations and aberrant expression of TCF3 have been implicated in several hematological malignancies, notably precursor B-cell acute lymphoblastic leukemia (ALL), where TCF3 is often found to be involved in translocations that disrupt normal function. Studying recombinant TCF3 protein allows researchers to investigate its structural and functional properties, providing insights into its role in gene regulation and potential therapeutic targets. This understanding may pave the way for innovative strategies in treating TCF3-related disorders and enhancing our comprehension of oncogenic mechanisms linked to transcription factors. The ability to manipulate TCF3 at the molecular level is, therefore, a promising area of inquiry for both basic and applied biomedical research.
