Analytical Data
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基因名
PKCb1
- Application
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别名
PKCb1；KIAA1125；PRKCBP1；RACK7；MYND-type zinc finger-containing chromatin reader ZMYND8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A452E543
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表达区间
1-1053aa
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氨基酸序列
DQVSTETVQKRKFPSPPHSSNGHSPQDTCTSPIKKKKKPGLLNNNNKEQPELRHGPFYYMKQPLTTDPVDVVPQDGRNDFHCWVCHQEGQVLCCELCPGVYHGDWFCPECEKITVAECIETQSKAMMMLTIEQLSYLLKFTIQKMKQPGTDEFQKPVPLEQHPDYAEYIFHPMDLCTLGKNAKKKMYGCTEAFLADAKWIWHNCIIYNGRNHKMTQITKVVIKIFCSECYLAACQKRDNWFCEPCSNPHPWVWAKLKGFPFWPAKALRDKDGQVDASWVPINNCYLMSKEIPFSVKKTKSIFNSIMQVMEVYVESIRRKFGVFNYSPFRIPYTPKSQYQMLLDPSNPSAGAAKMDKQEKVKLSFDMTVSPKILMSKPMLRGGSGCRISLSDMPRSPMSPNSSVQTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASSASTKTGQAGSLSGSLKPFSPQVSPVTTKMDKTSTTGSILNLNLHRSKAKMDLKELSESAQQQSAPVPLISPKRRIHSRFQLNLDETIESCKAQLGINEILEDKSNSSGSDSISDEEQNVPEDAKDKEGARMDKEPSASARHQAARNQGEDEPQPEKDFSDKAKPSPHSTKDKLKRKDETDSPTVHLGLDSDSENLGEDHSGQEDRKNKKEPKEPSPKQEVIGKAPPSMTAGSQSPPEMPVLTCSSSQTPTVGIMATTSTGSLAKKQRLLLPKETAPAVQRVMWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGTMITLASSVSTDLPIATVSADVTADIAKYTSKMMDAIKGVMTEIYNDLSKNTTGSTIAEIHRLRIETEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDLLIAEVKKQLELEKQQAVDETKMQQWCANCKKEAIFYCCWNTSYCDYPCQQAHWLEHMKSRTQLPPLSRKQTLSVQAAPPESSTLKEKETPAEKSKDSGSTLDLSGSKETPSSILLGSNQGSVSNRCDKQPASAPTSTDHQPHPNYTAQKYHSRSSKSSCWSGSKKRGSAHSEHNSSTSLKSLIPKESLLDTFWD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PKCb1 (Protein Kinase C beta 1) is a member of the protein kinase C (PKC) family, which plays a pivotal role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of PKCb1 has been implicated in numerous diseases, particularly cancer, where its altered function can contribute to tumorigenesis and metastasis. As a serine/threonine kinase, PKCb1 is activated by diacylglycerol and calcium ions, which underscores its significance in signal transduction pathways related to growth factor responsiveness and stress responses. The research surrounding PKCb1 has garnered attention due to its dual role as a tumor promoter and suppressor, depending on the tissue context and specific stimuli. Recent studies have focused on elucidating its precise molecular mechanisms and interactions with other signaling molecules, aiming to provide insights into its potential as a therapeutic target. The development of recombinant PKCb1 proteins has facilitated these investigations, allowing for detailed analyses of its biochemical properties, enzyme kinetics, and the impact of specific mutations. Understanding the functional landscape of PKCb1 is crucial for developing targeted therapies that can modulate its activity, ultimately contributing to better management strategies for PKCb1-related diseases. As research continues to unveil the complexities of PKCb1's role in cellular signaling, it holds promise for advancing our knowledge in cell biology and cancer therapeutics.
