Analytical Data
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Gene name
TBPL2
- Application
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Alternative Names
TATA binding protein 2; TATA box binding protein like 2; TATA box-binding protein-like 2; TATA box-binding protein-like protein 2; TATA box-binding protein-related factor 3; TATA-binding protein 2; TBP related factor 3; TBP-like protein 2; TBP-related factor 3; Tbpl2; TBPL2_HUMAN; TRF3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6SJ96
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Expression Region
1-375 aa
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AA Sequence
MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ DGLAPPRSPL FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT GAKERSEIYE AFENIYPILK GFKKA
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Molecular Weight
38.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBPL2 (TATA-binding protein-like 2) is a member of the TATA-binding protein (TBP) superfamily, which plays a crucial role in the regulation of gene transcription. Unlike its well-characterized counterpart, TBP, TBPL2 lacks the canonical TATA box-binding capability, suggesting a distinct yet pivotal function in the transcriptional regulation of specific genes. Research has indicated that TBPL2 is involved in various biological processes, including cell differentiation, growth, and response to cellular stress, linking it to critical pathways in development and disease. Its expression patterns are notably prominent in certain tissues like the brain and during specific developmental stages, highlighting its potential role in neurogenesis and other tissue-specific functions. Given the connection between TBPL2 and several pathological conditions, including cancer and neurodegenerative disorders, there is a growing interest in understanding its molecular mechanisms and interactions. Recent studies have aimed to characterize TBPL2 through recombinant protein expression systems, allowing for detailed examination of its functional properties, binding affinities, and effects on target gene regulation. This research not only enhances our understanding of TBPL2's role in transcriptional control but also provides insights into its potential as a therapeutic target in related diseases, making it a significant focus in the field of molecular biology and genetics.
