Analytical Data
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基因名
DUSP11
- Application
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别名
DUSP11; PIR1RNA/RNP complex-1-interacting phosphatase; EC 3.1.3.-; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75319
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表达区间
1-330aa
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氨基酸序列
MSQWHHPRSGWGRRRDFSGRSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYNLHQIQGHSAPRHFHTQTQSLQQSVRKFSENPHVYQRHHLPPPGPPGEDYSHRRYSWNVKPNASRAAQDRRRWYPYNYSRLSYPACWEWTQ
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分子量
65.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUSP11, a member of the dual-specificity phosphatase (DUSP) family, plays a crucial role in regulating various cellular signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target proteins. Understanding its biological functions is essential due to its involvement in important processes such as cell proliferation, differentiation, and apoptosis. Research on DUSP11 has gained traction in recent years, particularly concerning its implications in cancer biology and immune responses. Dysregulation of DUSP11 expression and activity has been linked to several diseases, including malignancies, highlighting its potential as a therapeutic target. Recombinant DUSP11 protein is utilized to investigate its enzymatic properties, substrate specificity, and interaction with other signaling molecules. These studies help elucidate the role of DUSP11 in pathological conditions and may pave the way for novel intervention strategies aimed at modulating its activity for clinical benefit. The generation of a recombinant form of DUSP11 allows for detailed biochemical assays and structural analyses, further contributing to our understanding of its function and regulation within the context of cellular signaling networks.
