Analytical Data
-
Gene name
VISA
- Application
-
Alternative Names
VISA；IPS1；KIAA1271；VISA；Mitochondrial antiviral-signaling Protein
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q7Z434
-
Expression Region
1-513aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPFAEDK TYKYICRNFS NFCNVDVVEI LPYLPCLTAR DQDRLRATCT LSGNRDTLWH LFNTLQRRPG WVEYFIAALR GCELVDLADE VASVYQSYQP RTSDRPPDPL EPPSLPAERP GPPTPAAAHS IPYNSCREKE PSYPMPVQET QAPESPGENS EQALQTLSPR AIPRNPDGGP LESSSDLAAL SPLTSSGHQE QDTELGSTHT AGATSSLTPS RGPVSPSVSF QPLARSTPRA SRLPGPTGSV VSTGTSFSSS SPGLASAGAA EGKQGAESDQ AEPIICSSGA EAPANSLPSK VPTTLMPVNT VALKVPANPA SVSTVPSKLP TSSKPPGAVP SNALTNPAPS KLPINSTRAG MVPSKVPTSM VLTKVSASTV PTDGSSRNEE TPAAPTPAGA TGGSSAWLDS SSENRGLGSE LSKPGVLASQ VDSPFSGCFE DLAISASTSL GMGPCHGPEE NEYKSEGTFG IHVAENPSIQ LLEGNPGPPA DPDGGPRPQA DRKFQEREVP CHRPSP
-
Molecular Weight
56 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VISA (Virus-induced signaling adaptor) is a pivotal protein involved in the innate immune response, particularly in the detection of viral infections. When viruses invade host cells, they often manipulate intracellular signaling pathways to evade immune responses. VISA acts as an adaptor molecule that facilitates the activation of downstream signaling cascades, ultimately leading to the production of type I interferons (IFNs), which are crucial for antiviral defense. The study of VISA has gained significant attention due to its role in mediating the host's immune response to diverse pathogens, including RNA viruses like influenza and various coronaviruses. Dysregulation of VISA signaling can result in impaired immune responses or excessive inflammation, contributing to disease pathology. Therefore, a detailed understanding of VISA structure and function, including the identification of its interaction partners and post-translational modifications, is essential for developing therapeutic strategies aimed at enhancing antiviral immunity or ameliorating autoimmune diseases. Recent advances in structural biology and biochemistry have provided insights into the mechanisms of VISA activation and its role in immune signaling, laying the groundwork for potential drug development and vaccine strategies that harness the body’s natural defense mechanisms against viral threats. Further research into VISA's functions could unravel novel therapeutic targets and enhance our understanding of host-pathogen interactions at a molecular level.
