Analytical Data
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基因名
TBC1D7
- Application
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别名
TBC1D7; TBC7; HSPC239; TBC1 domain family member 7; Cell migration-inducing protein 23
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P0N9
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表达区间
1-293 aa
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氨基酸序列
MTEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLDTE KLCTFSQRFP LPSMYRALVW KVLLGILPPH HESHAKVMMY RKEQYLDVLH ALKVVRFVSD ATPQAEVYLR MYQLESGKLP RSPSFPLEPD DEVFLAIAKA MEEMVEDSVD CYWITRRFVN QLNTKYRDSL PQLPKAFEQY LNLEDGRLLT HLRMCSAAPK LPYDLWFKRC FAGCLPESSL QRVWDKVVSG SCKILVFVAV EILLTFKIKV MALNSAEKIT KFLENIPQDS SDAIVSKAID LWHKHCGTPV HSS
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分子量
33.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D7 is a member of the TBC (Tre-2/BUB2/CDC16) domain-containing protein family, which is known to play crucial roles in cellular processes such as signaling, vesicular trafficking, and mitochondrial function. The protein is involved in the regulation of the small GTPase Rab, which is pivotal for intracellular transport and membrane trafficking. Recent studies have suggested that TBC1D7 may function as a RabGAP (GTPase-activating protein) that inactivates certain Rab proteins, thus influencing various cellular pathways. Its dysregulation has been implicated in several diseases, particularly cancer, where it may affect cellular proliferation and survival. Furthermore, TBC1D7 has been linked to metabolic pathways, illustrating its potential role in diseases related to metabolism. As researchers continue to explore the extensive functions of TBC1D7, the recombinant expression of this protein becomes essential for understanding its biochemical properties, interactions, and functional mechanisms in cellular contexts. The availability of recombinant TBC1D7 also facilitates structural studies, which can shed light on its role in disease pathology and offer insights for potential therapeutic interventions. With ongoing investigations, TBC1D7 is emerging as a significant factor in both basic and applied biomedical research, warranting further exploration of its complex roles in health and disease.
