Analytical Data
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基因名
PDP
- Application
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别名
PDP；PDP；PPM2C；[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P0J1
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表达区间
1-537aa
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氨基酸序列
MPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of PDP (Protein Disulfide Isomerase-like Protein) recombinant proteins has gained significant interest in the fields of molecular biology and biotechnology due to their crucial role in protein folding and maturation within cells. Protein disulfide isomerases, including PDPs, are essential enzymes that catalyze the formation and rearrangement of disulfide bonds during protein synthesis, ensuring the correct three-dimensional structure necessary for protein function. In various organisms, PDPs are implicated in critical physiological processes, such as cellular stress responses and the maintenance of protein homeostasis. With the rise of genetic engineering techniques, researchers have been able to produce recombinant PDPs, allowing for detailed studies of their mechanisms, functional roles, and interactions with other cellular components. Such investigations have profound implications for understanding diseases related to protein misfolding, such as Alzheimer’s and cystic fibrosis, where defective protein folding contributes to pathogenesis. Additionally, recombinant PDPs are explored for their potential applications in biopharmaceuticals, where enhancing protein stability and folding can improve the efficacy of therapeutic proteins. Thus, the research on PDP recombinant proteins not only enriches our fundamental understanding of cellular biology but also paves the way for innovative therapeutic strategies and biotechnological advancements.
