Analytical Data
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基因名
TBC1D3
- Application
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别名
TBC1D3; PRC17; TBC1D3A; TBC1 domain family member 3; Prostate cancer gene 17 protein; Protein TRE17-alpha; Rab GTPase-activating protein PRC17
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZP1
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表达区间
1-549 aa
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氨基酸序列
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQPCAPT SGPCLCGLHL ESSQFPPGF
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分子量
62.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D3 (TBC1 domain family member 3) is a member of the TBC1 domain-containing proteins, which are known to play crucial roles in cellular processes such as vesicle trafficking and movement of intracellular organelles. Research has highlighted TBC1D3's involvement in various cellular functions, particularly in the regulation of endosomal maturation and recycling pathways. Its association with diseases, especially cancer, makes it a compelling target for investigation. Notably, the upregulation of TBC1D3 has been observed in certain cancer types, suggesting a potential role in tumorigenesis and metastasis. The protein's structure includes a TBC domain, which is critical for its GTPase-activating protein (GAP) activity, and this function is pivotal in modulating RAB GTPases, key regulators in vesicular trafficking. The recombinant production of TBC1D3 has facilitated the study of its functional properties and interactions, thus providing insights into its biological significance. Understanding the molecular mechanisms underlying TBC1D3's actions could yield valuable information for therapeutic developments, particularly in targeting malignancies where TBC1D3 is implicated. Current research endeavors aim to elucidate its signaling pathways and assess its potential as a biomarker or therapeutic target, particularly in cancer treatment strategies and regenerative medicine.
