Analytical Data
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基因名
XAGE2
- Application
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别名
XAGE2; GAGED3; XAGE2BX antigen family member 2;
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96GT9
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表达区间
1-111 aa
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氨基酸序列
MSWRGRSTYRPRPRRSLQPPELIGAMLEPTDEEPKEEKPPTKSRNPTPDQKREDDQGAAEIQVPDLEADLQELCQTKTGDGCEGGTDVKGKILPKAEHFKMPEAGEGKSQV
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分子量
38.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XAGE2, a member of the cancer/testis (CT) antigen family, has garnered increasing interest in cancer research due to its restricted expression in normal tissues and prominent upregulation in various malignancies. As an immune target, XAGE2 is primarily expressed in germ cells of the testis, making it an ideal candidate for cancer immunotherapy, particularly in tumors where it is overexpressed, such as melanoma and certain types of lung cancer. Research has shown that XAGE2 can elicit T cell responses, suggesting its potential as a target for therapeutic vaccines. Furthermore, studies indicate that the presence of antibodies against XAGE2 correlates with improved patient prognosis, highlighting its relevance in tumor immunology. Investigating the recombinant protein forms of XAGE2 may provide valuable insights into its structural and functional characteristics, facilitating the development of novel immunotherapeutic strategies. This includes the generation of XAGE2-based vaccines and engineered T cell therapies, aiming to harness the immune system to specifically target cancer cells expressing this antigen. The exploration of XAGE2 recombinant proteins not only enhances our understanding of tumor immunity but also paves the way for personalized medicine approaches in oncology, where targeting CT antigens becomes a crucial strategy in developing effective cancer treatments. As research continues to unveil the complexities of the tumor microenvironment and immune interactions, XAGE2 stands out as a promising focal point for advancing cancer immunotherapy.












