Analytical Data
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Gene name
TBC1D2
- Application
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Alternative Names
TBC1D2; PARIS1; PP8997; TBC1D2A; TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYX2
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Expression Region
1-502 aa
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AA Sequence
MPIPWTASTSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA
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Molecular Weight
84.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBC1D2 is a member of the TBC (Tre-2/Bub2/CDC16) protein family, which is implicated in various cellular processes, particularly in the regulation of small GTPases involved in vesicle transport and cellular signaling. Research has indicated that TBC1D2 plays a crucial role in modulating intracellular trafficking pathways, specifically by acting as a GTPase-activating protein (GAP) for Rab GTPases, which are key regulators of the endocytic and exocytic pathways. Dysregulation of TBC1D2 has been associated with several diseases, including metabolic disorders and cancer, highlighting its importance in maintaining cellular homeostasis. Additionally, studies suggest that TBC1D2 may be involved in the regulation of insulin signaling and glucose homeostasis, making it a potential target for therapeutic intervention in diabetes. Recent findings have also explored TBC1D2's interactions with other proteins and its role in the intracellular environment, suggesting a broader impact on cell physiology. Understanding the functional mechanisms and pathways influenced by TBC1D2 can provide valuable insights into its biological significance and its potential as a biomarker or therapeutic target in various health conditions. Overall, TBC1D2 is a critical protein whose study could advance our knowledge of cellular dynamics and disease mechanisms, particularly in metabolic and endosomal trafficking contexts.
