Analytical Data
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基因名
TBC1D20
- Application
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别名
TBC1D20; C20orf140; TBC1 domain family member 20
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96BZ9
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表达区间
1-403 aa
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氨基酸序列
MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLAYHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
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分子量
72.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D20 is a protein encoded by the TBC1D20 gene, which is part of the TBC (Tre-2/BUB2/Cdc16) family of proteins known for their role in regulating intracellular trafficking and endosomal dynamics. Research has indicated that TBC1D20 is involved in autophagy and the maintenance of cellular homeostasis, particularly in the context of nutrient sensing and response. It is also implicated in the regulation of the mTOR (mechanistic target of rapamycin) signaling pathway, which is crucial for cell growth and metabolism. Dysregulation of TBC1D20 has been associated with various pathological conditions, including metabolic disorders and cancers, highlighting its potential as a therapeutic target. Additionally, studies have shown that TBC1D20 interacts with other proteins involved in vesicular transport, suggesting a complex network of signaling pathways that it may influence. Understanding the functional mechanisms of TBC1D20 and its role in cellular processes can provide insights into its contributions to health and disease, thereby opening avenues for novel interventions in conditions where TBC1D20 is dysregulated. Further research is needed to elucidate the specific molecular interactions and pathways involved, as well as to explore the potential of TBC1D20 as a biomarker for disease progression and treatment response.
