Analytical Data
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Gene name
DTNA
- Application
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Alternative Names
Alpha-dystrobrevin; D18S892E; DRP3; DTN; DTN-A; DTNA; DTNA_HUMAN; Dystrobrevin alpha; Dystrophin related protein 3; Dystrophin-related protein 3; FLJ96209; LVNC1; OTTHUMP00000163151; OTTHUMP00000163152; OTTHUMP00000163153; OTTHUMP00000163154; OTTHUMP00000163155
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y4J8
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Expression Region
1-743aa
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AA Sequence
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE ALRENALNNL DPNTELNVSR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF SHSVPSSGSP FITRSSPPKD SEVEQNKLLA RAAPAFLKGK GIQYSLNVAD RLADEHVLIG LYVNMLRNNP SCMLESSNRL DEEHRLIARY AARLAAESSS SQPPQQRSAP DISFTIDANK QQRQLIAELE NKNREILQEI QRLRLEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR ELMVQLEGLM KLLKTQGAGS PRSSPSHTIS RPIPMPIRSA SACSTPTHTP QDSLTGVGGD VQEAFAQSSR RNLRNDLLVA ADSITNTMSS LVKELNSEVG SETESNVDSE FARTQFEDLV PSPTSEKAFL AQIHARKPGY IHSGATTSTM RGDMVTEDAD PYVQPEDENY ENDSVRQLEN ELQMEEYLKQ KLQDEAYQVS LQG
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Molecular Weight
83.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DTNA (Dystrobrevins, a member of the dystrophin-associated protein complex) is a protein that plays a crucial role in maintaining muscular and neuronal function. The study of DTNA and its recombinant forms has gained significance due to its involvement in various pathophysiological conditions, particularly in muscle disorders and neurodegenerative diseases. Research indicates that DTNA is essential for the structural integrity of muscle fibers and synapses, linking intracellular signaling pathways to the cellular matrix. Deficiencies or mutations in DTNA can lead to conditions such as muscular dystrophy, highlighting the need for a deeper understanding of its molecular mechanisms. The recombinant production of DTNA allows researchers to explore its functional properties, interactions with other proteins, and potential therapeutic targets. Additionally, the availability of DTNA as a recombinant protein facilitates the development of diagnostic tools and the study of disease mechanisms at a molecular level. The exploration of DTNA’s structure-function relationship offers promising avenues for the advancement of treatments for muscular and neurological disorders. Overall, the investigation of DTNA recombinant protein represents a critical area of research with implications for understanding and addressing various health challenges.
