Analytical Data
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Gene name
TBC1D19
- Application
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Alternative Names
2810453K03Rik; FLJ11082; RGD1304958; TBC1 domain family member 19; TBC19_HUMAN; TBC1D19
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5T2
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Expression Region
1-526 aa
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AA Sequence
MLQEESDLSL IIAQIVQKLK GSNLYSQLER QAWASLQRPE IKLESLKEDI KEFFKISGWE KKLQNAVYSE LSVFPLPSHP AAPPEHLKEP LVYMRKAQGS WEKRILKSLN SMCTELSIPL ARKRPVGEQK ELLNKWNEMG TDEPDLSLFR PVYAPKDFLE VLINLRNPNY ENGDSLSFRT HLGLIQVPLK VKDIPELKEC FVELGLNIGQ LGIDDSTQVP PELFENEHVR IGQKVLAEQD SAAAQQYIRQ GSPTALRAEL WALILNISSQ PEDVLYYEQL KTNVIQHDLL VDSLIYKDVK LTASNDDYYF VFEDYLYQVL LCFSRDTSVL SHFAFNSASP PKSYIRGKLG LEEYAVFYPP NGVIPFHGFS MYVAPLCFLY HEPSKLYQIF REMYVRFFFR LHSISSHPSG IVSLCLLFET LLQTYLPQLF YHLREIGAQP LRISFKWMVR AFSGYLATDQ LLLLWDRILG YNSLEILAVL AAAVFAFRAV NLMEVTSLAA AEAVLADLST LKVMPLLQIF LFATVT
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Molecular Weight
60.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBC1D19 is a member of the TBC (Tre-2/BUB2/Cdc16) protein family, which plays a critical role in cellular processes such as endosomal trafficking and regulating cellular signaling pathways. The gene encoding TBC1D19 has garnered considerable interest due to its involvement in various cellular functions that are essential for maintaining cellular homeostasis and responding to environmental stimuli. Research has shown that TBC1D19 is implicated in the regulation of insulin signaling, which is crucial for glucose homeostasis, and may contribute to metabolic disorders such as obesity and type 2 diabetes. Furthermore, mutations or dysregulation of TBC1D19 have been linked to neurological diseases, suggesting that it may also have a role in neuronal function and development. Understanding the precise mechanisms through which TBC1D19 exerts its effects is of paramount importance for developing therapeutic strategies to combat these conditions. Recent studies employing recombinant TBC1D19 proteins have provided insights into its structural properties and functional domains, paving the way for further investigations into its biological roles. The integration of biochemical, molecular biology, and cell biology approaches to study TBC1D19 is expected to reveal novel insights into its contribution to disease pathology and identify potential biomarkers for metabolic and neurological disorders.
