Analytical Data
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基因名
WSB2
- Application
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别名
WSB2; WD repeat and SOCS box-containing Protein 2; WSB-2; CS box-containing WD Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYS7
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表达区间
1-404 aa
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氨基酸序列
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCIV KLIPWPLEEQ FIPKGFEAKS RSSKNETKGR GSPKEKTLDC GQIVWGLAFS PWPSPPSRKL WARHHPQVPD VSCLVLATGL NDGQIKIWEV QTGLLLLNLS GHQDVVRDLS FTPSGSLILV SASRDKTLRI WDLNKHGKQI QVLSGHLQWV YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS SVVSCDFSPD SALLVTASYD TNVIMWDPYT GERLRSLHHT QVDPAMDDSD VHISSLRSVC FSPEGLYLAT VADDRLLRIW ALELKTPIAF APMTNGLCCT FFPHGGVIAT GTRDGHVQFW TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT YRTF
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分子量
45.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WSB2 (WSB Homolog 2) is a protein that plays a critical role in various cellular processes, including protein degradation and signaling pathways. Its involvement in cellular stress responses and the regulation of protein homeostasis has garnered significant attention in the field of molecular biology. Research has shown that WSB2 functions as a substrate recognition component of the E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins. This process is crucial for maintaining cellular integrity and function, particularly under conditions of stress or abnormal signaling. Moreover, aberrations in WSB2 function have been linked to various diseases, including cancer, where dysregulated protein turnover can contribute to tumorigenesis. Consequently, the study of WSB2 and its interactions with other cellular components is integral to understanding not only fundamental biological processes but also the molecular underpinnings of disease. As such, ongoing research aims to elucidate the precise mechanisms by which WSB2 operates, its protein interactions, and its potential as a therapeutic target, highlighting its significance in both basic and translational research contexts.
