Analytical Data
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基因名
TBC1D10B
- Application
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别名
TBC1D10B; FP2461; TBC1 domain family member 10B; Rab27A-GAP-beta
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q4KMP7
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表达区间
1-533 aa
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氨基酸序列
MSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRPSAEARQDAYF
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分子量
58.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D10B is a member of the TBC (Tre-2/Bub2/Cdc16) domain-containing protein family, which is known to play significant roles in various cellular processes, including Rab GTPase regulation and vesicle trafficking. Research has indicated that TBC1D10B is involved in the modulation of cellular signaling pathways and exocytosis, making it crucial in maintaining cellular homeostasis and function. Its dysregulation has been implicated in several diseases, such as cancer and neurological disorders, highlighting its potential as a therapeutic target. Studies have suggested that TBC1D10B may interact with several Rab proteins, thus influencing their activity and localization within the cell. The exploration of TBC1D10B recombinant proteins facilitates a deeper understanding of its function and interactions, aiding in the elucidation of its role in cellular dynamics and disease pathology. Given the importance of Rab GTPases in various physiological processes, research on TBC1D10B could provide insights into novel mechanisms of disease development and uncover new avenues for targeted therapies. This makes the study of TBC1D10B a promising area of investigation within the fields of molecular biology and biomedical research.
