Analytical Data
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Gene name
WHSC1L1
- Application
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Alternative Names
DKFZp667H044; FLJ20353; Histone lysine N methyltransferase NSD3; Histone-lysine N-methyltransferase NSD3; MGC126766; MGC142029; NSD 3; NSD3_HUMAN; Nuclear set domain containing 3; Nuclear SET domain containing Protein 3; Nuclear SET domain-containing Protein 3; pp14328; Protein whistle; Whistle; WHSC1 like Protein 1; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; WHSC1-like Protein 1; WHSC1L1; WHSC1L1 Protein; Wolf Hirschhorn syndrome candidate 1 like 1; Wolf-Hirschhorn syndrome candidate 1-like Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZ95
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Expression Region
1-645 aa
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AA Sequence
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGSADRGVQGSVRFSDSSVSAAIEETVD
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Molecular Weight
73.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WHSC1L1, also known as Wolf-Hirschhorn syndrome candidate 1-like 1, is a gene that encodes a protein involved in various cellular processes, including gene regulation, chromatin remodeling, and DNA repair. This protein is a homolog of WHSC1, which is associated with Wolf-Hirschhorn syndrome, a genetic disorder characterized by developmental delays, distinct facial features, and other congenital anomalies. Despite the clinical significance of WHSC1 mutations, the role of WHSC1L1 in cellular physiology and its potential implications in human diseases remain to be elucidated. Recent studies have suggested that WHSC1L1 plays a crucial role in hematopoiesis and may influence the progression of certain malignancies. Researchers are particularly interested in WHSC1L1 due to its involvement in the epigenetic regulation of gene expression, which could have far-reaching implications in cancer biology and therapeutic interventions. Furthermore, understanding the structure-function relationship of WHSC1L1, along with its interactions with other cellular components, could provide insights into its biological roles and pave the way for novel treatment strategies targeting related disorders. Given its potential implications in both developmental disorders and cancer, WHSC1L1 is emerging as a significant focus area for ongoing research, aiming to uncover its mechanisms of action and therapeutic potential.
