Analytical Data
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Gene name
FOXA2
- Application
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Alternative Names
FOXA2；HNF3B；TCF3B；Hepatocyte nuclear factor 3-beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y261
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Expression Region
1-457aa
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AA Sequence
MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FOXA2, a member of the Forkhead box (Fox) family of transcription factors, plays a crucial role in various biological processes, including organogenesis, metabolism, and cellular differentiation. Researchers have shown that FOXA2 is particularly significant in the development and function of the pancreas and lungs, and it is also involved in regulating metabolic pathways, such as glucose homeostasis. Its role in these processes has drawn attention to its potential implications in diseases like diabetes and lung disorders. The study of FOXA2 recombinants has gained traction as scientists seek to understand its mechanisms of action at the molecular level. By exploring its interactions with other proteins and its impact on gene expression, researchers aim to unravel the complexities of FOXA2's function. Recombining FOXA2 allows for the generation of mutant forms that can elucidate specific functional domains and interactions, providing insights that could lead to novel therapeutic strategies. Due to its pivotal role in critical biological functions, FOXA2 and its recombinant forms have become a focal point for studies aiming to develop innovative treatments targeting metabolic and respiratory diseases. The continued investigation into FOXA2's structure and function, alongside advances in recombinant technology, promises to enhance our understanding of various pathological conditions and may pave the way for new avenues in disease management.
