Analytical Data
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基因名
DOK2
- Application
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别名
Docking protein 2 56kDa; Docking protein 2; DOK 2; DOK R; DOK2; DOK2_HUMAN; Downstream of tyrosine kinase 2; OTTHUMP00000161710
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60496
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表达区间
1-412aa
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氨基酸序列
MGDGAVKQGF LYLQQQQTFG KKWRRFGASL YGGSDCALAR LELQEGPEKP RRCEAARKVI RLSDCLRVAE AGGEASSPRD TSAFFLETKE RLYLLAAPAA ERGDWVQAIC LLAFPGQRKE LSGPEGKQSR PCMEENELYS SAVTVGPHKE FAVTMRPTEA SERCHLRGSY TLRAGESALE LWGGPEPGTQ LYDWPYRFLR RFGRDKVTFS FEAGRRCVSG EGNFEFETRQ GNEIFLALEE AISAQKNAAP ATPQPQPATI PASLPRPDSP YSRPHDSLPP PSPTTPVPAP RPRGQEGEYA VPFDAVARSL GKNFRGILAV PPQLLADPLY DSIEETLPPR PDHIYDEPEG VAALSLYDSP QEPRGEAWRR QATADRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG PK
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分子量
45.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOK2, or Docking Protein 2, is a critical member of the DOK protein family that plays a significant role in various cellular processes, including signal transduction, cell proliferation, and differentiation. Research into DOK2 has gained momentum due to its involvement in several diseases, particularly cancer and obesity. DOK2 acts as a scaffolding protein and interacts with different signaling molecules and pathways, which can influence cellular responses to external stimuli. The interest in recombinant DOK2 proteins has surged as scientists seek to understand its functional mechanisms at a molecular level and its potential as a therapeutic target. By producing recombinant DOK2 proteins, researchers aim to elucidate its interactions with other proteins and its role in specific signaling cascades. This has implications for the development of targeted therapies, particularly in oncological settings where DOK2 dysregulation is implicated. Furthermore, exploring the structural characteristics and functional domains of DOK2 through recombinant protein studies could provide insights into its biological importance and open avenues for innovative treatment strategies. Overall, the investigation of DOK2 through the lens of recombinant protein technology presents a promising area of research, with the potential to contribute significantly to our understanding of disease mechanisms and the development of novel therapeutic interventions.
