Analytical Data
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Gene name
WDR48
- Application
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Alternative Names
p80; UAF 1; UAF1; USP1 associated factor 1; USP1-associated factor 1; WD repeat containing Protein 48; WD repeat domain 48; WD repeat endosomal Protein; WD repeat-containing Protein 48; WDR 48; WDR48; WDR48_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TAF3
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Expression Region
1-677 aa
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AA Sequence
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM ELDRSADPPP AIWVATTKST VNKWTLKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF IWKSGGDLTL HYRQKST
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Molecular Weight
76.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR48, also known as WD repeat domain 48, is a protein that plays a significant role in various cellular processes, including protein degradation and signaling pathways. Its function is closely associated with the regulation of the ubiquitin-proteasome system, which is crucial for maintaining intracellular protein homeostasis. As a member of the WD repeat protein family, WDR48 contains multiple WD domains that facilitate protein-protein interactions, particularly with components of the proteasome. Recent studies have highlighted its involvement in critical biological functions such as DNA repair, cell cycle regulation, and responses to cellular stress. The dysregulation of WDR48 has been linked to several diseases, including cancer, making it an important target for therapeutic interventions. Research on WDR48 involves investigating its structural properties, interaction networks, and functional implications in various cellular contexts. Understanding the role of WDR48 in these processes is essential for developing novel strategies to modulate its activity in disease states, thereby offering potential avenues for targeted therapies. The recombinant expression and purification of WDR48 are crucial for biochemical and biophysical studies, allowing researchers to elucidate its mechanisms of action and identify potential inhibitors or modulators. This growing body of research underscores the significance of WDR48 in cellular biology and its potential as a biomarker or therapeutic target in disease management.
