Analytical Data
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Gene name
WDR45L
- Application
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Alternative Names
WD repeat domain phosphoinositide-interacting Protein 3; WD repeat Protein 45 like; WD repeat-containing Protein 45-like; WDR4 like; WDR45 like Protein; WDR45-like Protein; wdr45l; WIPI 3; WIPI-3; WIPI3; WIPI3_HUMAN; WIPI49 like Protein; WIPI49-like Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5MNZ6
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Expression Region
1-344 aa
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AA Sequence
MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL
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Molecular Weight
38.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR45L (WD repeat domain 45-like) is a gene that encodes a protein involved in various cellular processes, including autophagy, neuronal development, and synaptic function. Recent studies have highlighted its crucial role in neurodevelopmental disorders, particularly those associated with intellectual disability and epilepsy. The WDR45L protein is part of the WD-repeat protein family, which is characterized by the presence of multiple WD motifs that facilitate protein-protein interactions. This makes WDR45L integral to many signaling pathways. Emerging research indicates that mutations or dysregulation of WDR45L can disrupt its function, leading to cellular stress and neuronal impairment. Understanding WDR45L's structure and function through recombinant protein expression is vital for elucidating its role in health and disease. By producing WDR45L as a recombinant protein, researchers can investigate its biochemical properties, interactions with other proteins, and responses to cellular stressors. This knowledge may open new avenues for targeted therapies in conditions linked to WDR45L dysfunction, such as specific forms of epilepsy and intellectual disabilities, underscoring the importance of this protein in neuroscience and molecular biology. The ongoing characterization of WDR45L is expected to provide deeper insights into its function and therapeutic potential, solidifying its importance as a research focus in the fields of genetics and neurobiology.
