Analytical Data
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Gene name
SYCE1
- Application
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Alternative Names
SYCE1; C10orf94; Synaptonemal complex central element protein 1; Cancer/testis antigen 76; CT76
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N0S2
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Expression Region
1-351 aa
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AA Sequence
MAGRSLTSKA EPTAGAVDRA EKAGGQDTSS QKIEDLMEMV QKLQKVGSLE PRVEVLINRI NEVQQAKKKA NKDLGEARTI CEALQKELDS LHGEKVHLKE ILSKKQETLR ILRLHCQEKE SEAHRKHTML QECKERISAL NLQIEEEKNK QRQLRLAFEE QLEDLMGQHK DLWDFHMPER LAKEICALDS SKEQLLKEEK LVKATLEDVK HQLCSLCGAE GPSTLDEGLF LRSQEAAATV QLFQEEHRKA EELLAAAAQR HQQLQQKCQQ QQQKRQRLKE ELEKHGMQVP AQAQSTQEEE AGPGDVASPK PLKGERPGAA HQAGPDVLIG QEDTLHPDLS PRGFQEIKEL F
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Molecular Weight
39.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYCE1 (SYNCRIP1) is a critical protein involved in the regulation of meiotic chromosome pairing and synapsis during gametogenesis. Research on SYCE1 has gained prominence due to its essential role in fertility and its association with male infertility and certain genetic disorders. This protein is part of the SYCP structure, which facilitates the assembly of the synaptonemal complex, a pivotal structure that forms between homologous chromosomes during meiosis. Deficiencies or mutations in SYCE1 have been linked to impaired spermatogenesis and are believed to contribute to reproductive challenges in various species, including humans. The study of SYCE1 recombinant proteins offers valuable insights into its functional mechanisms, interactions with other meiosis-related proteins, and the pathways involved in cellular processes. Understanding how SYCE1 operates at a molecular level is vital for elucidating its role in fertility and can have broader implications in reproductive biology and the development of potential therapeutic strategies for infertility. To this end, recombinant SYCE1 proteins are employed in various biochemical and biophysical assays, paving the way for advancements in both basic biology and clinical applications. These studies not only enhance our comprehension of meiotic processes but also provide the foundation for novel approaches to addressing reproductive health issues linked to chromosomal abnormalities.
