Analytical Data
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基因名
SWAP70
- Application
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别名
KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UH65
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表达区间
1-585 aa
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氨基酸序列
MGSLKEELLK AIWHAFTALD QDHSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD EGPVSNQGYM PYLNRFILEK VQDNFDKIEF NRMCWTLCVK KNLTKNPLLI TEEDAFKIWV IFNFLSEDKY PLIIVSEEIE YLLKKLTEAM GGGWQQEQFE HYKINFDDSK NGLSAWELIE LIGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMMKK GHRRKNWTER WFVLKPNIIS YYVSEDLKDK KGDILLDENC CVESLPDKDG KKCLFLVKCF DKTFEISASD KKKKQEWIQA IHSTIHLLKL GSPPPHKEAR QRRKELRKKQ LAEQEELERQ MKELQAANES KQQELEAVRK KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQAIQTTEA EKQELENQRV LKEQALQEAM EQLEQLELER KQALEQYEEV KKKLEMATNK TKSWKDKVAH HEGLIRLIEP GSKNPHLITN WGPAAFTEAE LEEREKNWKE KKTTE
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分子量
68.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SWAP70 is a multifunctional protein that plays a crucial role in various cellular processes, particularly in immune cell function and signal transduction. Initially identified as a protein associated with the stimulation of B cells, SWAP70 has since been implicated in a range of biological functions, including cytoskeletal rearrangement, adhesion, and migration of lymphocytes. Its structure features several functional domains, including a pleckstrin homology (PH) domain, which facilitates its interaction with phosphoinositides and contributes to membrane localization. Research has shown that SWAP70 is involved in the regulation of actin dynamics, amplifying signals from various receptors such as the B cell receptor (BCR). This makes it an attractive target for understanding immune responses and potential therapeutic interventions for autoimmune diseases and cancer. Recent studies have highlighted its role in T cell activation and differentiation, emphasizing its importance in adaptive immunity. Moreover, the generation of recombinant SWAP70 protein has enabled detailed examinations of its function at the molecular level, paving the way for novel insights into its contribution to immune cell signaling pathways. Overall, the investigation of SWAP70 and its functions continues to be an important area of research, with implications for both basic biology and clinical applications.
