Analytical Data
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Gene name
SV2C
- Application
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Alternative Names
SV2C; KIAA1054; Synaptic vesicle glycoprotein 2C
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q496J9
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Expression Region
1-727 aa
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AA Sequence
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM
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Molecular Weight
108.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SV2C (Synaptic Vesicle Protein 2C) is a critical member of the synaptic vesicle glycoprotein family, playing a pivotal role in neurotransmitter release and synaptic function. It is predominantly expressed in neurons, particularly in the brain regions associated with dopaminergic signaling, and is involved in the regulation of vesicular transport and dopamine release, which makes it a key player in various neurological processes. Research has indicated that abnormalities in SV2C function may contribute to the pathophysiology of neurodegenerative diseases, such as Parkinson's disease and schizophrenia, where dopaminergic signaling is disrupted. Moreover, SV2C has emerged as a potential drug target for novel therapeutics aimed at modulating neurotransmitter release and improving synaptic transmission. Recent advances in protein engineering and recombinant DNA technology have enabled the production of SV2C as a recombinant protein, enhancing the ability to study its structure-function relationships and interactions with other synaptic proteins. This research not only deepens our understanding of the fundamental mechanisms underlying synaptic transmission but also opens new avenues for the development of strategies to treat neurological disorders linked to SV2C dysregulation. Given its importance in the central nervous system, the study of SV2C and its recombinant forms is essential for elucidating its role in neurotransmission and for identifying potential therapeutic interventions in synaptic dysfunction.
