Analytical Data
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基因名
SV2C
- Application
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别名
SV2C; KIAA1054; Synaptic vesicle glycoprotein 2C
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q496J9
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表达区间
1-727 aa
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氨基酸序列
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM
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分子量
108.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SV2C (Synaptic Vesicle Protein 2C) is a critical member of the synaptic vesicle glycoprotein family, playing a pivotal role in neurotransmitter release and synaptic function. It is predominantly expressed in neurons, particularly in the brain regions associated with dopaminergic signaling, and is involved in the regulation of vesicular transport and dopamine release, which makes it a key player in various neurological processes. Research has indicated that abnormalities in SV2C function may contribute to the pathophysiology of neurodegenerative diseases, such as Parkinson's disease and schizophrenia, where dopaminergic signaling is disrupted. Moreover, SV2C has emerged as a potential drug target for novel therapeutics aimed at modulating neurotransmitter release and improving synaptic transmission. Recent advances in protein engineering and recombinant DNA technology have enabled the production of SV2C as a recombinant protein, enhancing the ability to study its structure-function relationships and interactions with other synaptic proteins. This research not only deepens our understanding of the fundamental mechanisms underlying synaptic transmission but also opens new avenues for the development of strategies to treat neurological disorders linked to SV2C dysregulation. Given its importance in the central nervous system, the study of SV2C and its recombinant forms is essential for elucidating its role in neurotransmission and for identifying potential therapeutic interventions in synaptic dysfunction.
