Analytical Data
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基因名
SURB7
- Application
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别名
Mediator of RNA polymerase II transcription subunit 21. Mediator complex subunit 21. RNA polymerase II holoenzyme component SRB7. RNAPII complex component SRB7. hSrb7
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13503
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表达区间
1-144 aa
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氨基酸序列
MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS
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分子量
41.58 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SURB7, a protein involved in human cellular processes, has gained attention due to its role in various physiological and pathological contexts, including cell signaling, proliferation, and differentiation. As a member of the SURB family, SURB7 plays a critical role in regulating the splicing of pre-mRNA and has been implicated in several diseases, particularly cancers, where altered splicing can lead to aberrant gene expression. Research indicates that SURB7 interacts with specific RNA-binding proteins, contributing to the modulation of spliceosomal complexes and influencing the overall splicing landscape within cells. Additionally, studies have suggested that SURB7 may have a regulatory impact on cellular responses to stress and may act as a potential biomarker for certain conditions. Understanding the structure and function of SURB7, including the development of recombinant forms of the protein, is essential for elucidating its mechanistic roles and potential therapeutic applications. By harnessing advanced techniques in molecular biology and biochemistry, researchers aim to explore the functional properties of SURB7 and its implications in disease states, paving the way for novel interventions and improved diagnostic tools. Thus, the investigation of SURB7 recombinant proteins holds promise for enhancing our understanding of post-transcriptional regulation and its impact on human health.
