Analytical Data
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基因名
SUPV3L1
- Application
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别名
6330443E10Rik ; ATP dependent RNA helicase SUPV3L1; mitochondrial; ATP-dependent RNA helicase SUPV3L1; EC 3.6.1.; MGC109049; mitochondrial; OTTHUMP00000019719; S. Cerevisiae suppressor of var 1 3 like 1; suppressor of var1 (S.cerevisiae) 3 like 1; Suppressor of var1 3 like 1 (S. cerevisiae); Suppressor of var1 3 like 1 (S. cerevisiae)(SUV3); Suppressor of var1 3 like 1; Suppressor of var1 3 like protein 1; Suppressor of var1 3-like protein 1; SUPV 3 L 1; SUPV3L1; SUV 3; SUV 3 L 1; SUV3; SUV3 like protein 1; SUV3-like protein 1; SUV3_HUMAN; SUV3L1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IYB8
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表达区间
23-786 aa
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氨基酸序列
AICSALRP HFGPFPGVLG QVSVLATASS SASGGSKIPN TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKVLDKF YKRKEIQKLG ADYGLDARLF HQAFISFRNY IMQSHSLDVD IHIVLNDICF GAAHADDLFP FFLRHAKQIF PVLDCKDDLR KISDLRIPPN WYPDARAMQR KIIFHSGPTN SGKTYHAIQK YFSAKSGVYC GPLKLLAHEI FEKSNAAGVP CDLVTGEERV TVQPNGKQAS HVSCTVEMCS VTTPYEVAVI DEIQMIRDPA RGWAWTRALL GLCAEEVHLC GEPAAIDLVM ELMYTTGEEV EVRDYKRLTP ISVLDHALES LDNLRPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP PGTKLAQAKK FNDPNDPCKI LVATDAIGMG LNLSIRRIIF YSLIKPSINE KGERELEPIT TSQALQIAGR AGRFSSRFKE GEVTTMNHED LSLLKEILKR PVDPIRAAGL HPTAEQIEMF AYHLPDATLS NLIDIFVDFS QVDGQYFVCN MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVLDLYLW LSYRFMDMFP DASLIRDLQK ELDGIIQDGV HNITKLIKMS ETHKLLNLEG FPSGSQSRLS GTLKSQARRT RGTKALGSKA TEPPSPDAGE LSLASRLVQQ GLLTPDMLKQ LEKEWMTQQT EHNKEKTESG THPKGTRRKK KEPDSD
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分子量
87.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SUPV3L1, or Suppressor of Variegation 3-9 Homolog 1, is a gene that encodes a single-stranded DNA translocase, playing a crucial role in various cellular processes, particularly in the maintenance of genomic stability and response to DNA damage. The research surrounding SUPV3L1 has gained significant interest due to its involvement in mitochondrial function and the potential links to several diseases, including neurodegenerative disorders and cancers. The protein is known to localize in mitochondria and is thought to contribute to mitochondrial DNA replication and repair, which are vital for the integrity of cellular energy metabolism. Mutations or dysregulation of SUPV3L1 have been associated with defects in mtDNA maintenance, leading to increased mutations and metabolic dysfunction. Understanding the structural and functional characteristics of the SUPV3L1 recombinant protein can provide insights into its mechanisms of action and its role in cellular homeostasis. Advances in technologies such as CRISPR and advanced sequencing have facilitated the investigation of SUPV3L1's role in pathophysiological contexts, allowing for a deeper exploration of its therapeutic potential. Continued research on SUPV3L1 and its recombinant protein is expected to illuminate new avenues for developing targeted therapies for diseases associated with mitochondrial dysfunction and genomic instability, emphasizing the importance of this protein in both basic and applied biomedical research.
