Analytical Data
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Gene name
WBSCR28
- Application
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Alternative Names
TMEM270; WBSCR28; Transmembrane Protein 270; Williams-Beuren syndrome chromosomal region 28 Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UE05
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Expression Region
1-265 aa
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AA Sequence
MEALPPVRSSLLGNLLQVTRLSVLLVQNRDHLYNFLLLKINLFNHWVSGLAQEARGSCNWQAHLPLGAADCPLGQALRAGLALIQVPVWLVLQGPRLMWAGMWGSTKGLGLALLSAWEQLGLSVAIWTDLFLSCLHGLMLVALLLVVVTWRVCQKSHCFRLGRQLSKALQVNCVVRKLLVQLRRLYWWVETMTALTSWHLAYLITWTTCLASHLLQAAFEHTTQLAEAQEVEPQEVSGSSLLPSLSASSDSESGTVLPEQETPRE
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Molecular Weight
55.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WBSCR28, a protein associated with Williams-Beuren syndrome, plays a crucial role in various cellular functions, including gene expression regulation and RNA processing. Williams-Beuren syndrome is a genetic disorder caused by a deletion of genetic material on chromosome 7, which can lead to a range of developmental and cognitive challenges. Research into WBSCR28 focuses on understanding its structure, function, and the mechanisms by which it may contribute to the phenotype observed in affected individuals. Recent studies suggest that WBSCR28 may interact with other proteins implicated in cellular signaling pathways, and its dysregulation could impact neurological development. Given the significance of this protein in both health and disease, the investigation of its recombinant form presents a valuable opportunity to elucidate its biochemical properties, explore potential therapeutic targets, and provide insights into the underlying mechanisms of Williams-Beuren syndrome. This research could pave the way for developing novel interventions aimed at ameliorating the symptoms associated with this condition, thus enhancing the quality of life for those affected.
