Analytical Data
-
Gene name
WBSCR1
- Application
-
Alternative Names
AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF 4H; eIF-4H; EIF4H; Eukaryotic translation initiation factor 4H; IF4H_HUMAN; KIAA0038 ; WBSCR1; Williams Beuren syndrome chromosomal region 1 Protein homolog ; Williams Beuren syndrome chromosome region 1; Williams-Beuren syndrome chromosomal region 1 Protein; Williams-Beuren syndrome chromosome region 1; WSCR1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q15056
-
Expression Region
2-248 aa
-
AA Sequence
ADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE
-
Molecular Weight
27.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WBSCR1, also known as Williams Beuren Syndrome Critical Region Gene 1, is a protein whose study is largely driven by its involvement in Williams-Beuren syndrome (WBS), a genetic disorder characterized by developmental delays, cardiovascular issues, and distinctive facial features. The gene is located within a critical region of deletion on chromosome 7q11.23, which is often affected in individuals with WBS. Research on WBSCR1 has gained momentum due to its potential role in neurodevelopment and cellular signaling pathways. Studies suggest that WBSCR1 may influence processes such as cell proliferation, differentiation, and apoptosis, making it a focus of interest for understanding the molecular mechanisms underlying WBS and associated neurodevelopmental disorders. Furthermore, exploring the functional aspects of WBSCR1 can shed light on its biological significance and potential therapeutic targets. Investigating the structure and function of the WBSCR1 protein aims to elucidate its specific roles within cellular contexts and contribute to the broader understanding of genetic syndromes that affect cognitive and physical development. As ongoing studies continue to reveal the implications of WBSCR1 in both normal physiology and disease pathology, there is considerable interest in leveraging this knowledge for developing innovative strategies for intervention and management of WBS and related conditions.
