Analytical Data
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Gene name
SPTAN1
- Application
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Alternative Names
SPTAN1；NEAS；SPTA2；Spectrin alpha chain. non-erythrocytic 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13813
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Expression Region
1-580aa
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AA Sequence
MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFR
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Molecular Weight
83.8kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPTAN1, also known as Spectrin Alpha Non-Erythrocytic 1, is a crucial cytoskeletal protein that plays a significant role in maintaining cell structure and function. It is primarily expressed in neural tissues, where it is involved in the organization of the cytoskeleton, influencing cellular processes such as membrane stability, signal transduction, and cell migration. Mutations in the SPTAN1 gene have been linked to various neurological disorders, including epilepsy and developmental delays, highlighting its importance in neural development and function. Researchers have increasingly focused on the study of SPTAN1 recombinant proteins to elucidate its structure-function relationship and understand the molecular mechanisms underlying its role in neurodevelopmental processes. By investigating the properties of SPTAN1 recombinant proteins, scientists aim to uncover potential therapeutic targets for disorders associated with SPTAN1 mutations. Furthermore, the successful expression and characterization of SPTAN1 recombinant proteins in various systems can aid in developing diagnostic tools and therapeutic strategies, providing insight into the pathophysiology of diseases linked to this protein. Overall, the research on SPTAN1 recombinant proteins is essential for advancing our understanding of its biological significance and potential applications in medicine.
