Analytical Data
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基因名
DNAJC5B
- Application
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别名
DNAJC5BDnaJ homolog subfamily C member 5B; Cysteine string protein beta; CSP-beta
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UF47
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表达区间
1-199
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氨基酸序列
MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN ANEKTQLIKE GSRSYCTDS
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分子量
22.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJC5B is a member of the DnaJ family of proteins, which are known for their roles as molecular chaperones involved in protein folding and stress responses. The research on DNAJC5B has gained momentum due to its implications in neurodegenerative diseases and its essential role in cellular processes such as autophagy and protein degradation. Mutations in the DNAJC5B gene have been linked to conditions like adult-onset neuronal ceroid lipofuscinosis (CLN4), a disorder characterized by progressive neurodegeneration and cognitive decline. Understanding the functional properties of DNAJC5B and its interactions with other cellular components is crucial for elucidating the mechanisms underlying these diseases. Recent studies have focused on the structural characteristics and the chaperone activity of DNAJC5B, providing insights into its functional dynamics. Additionally, the development of recombinant DNAJC5B proteins has enabled researchers to conduct in vitro studies, facilitating a better understanding of its role in protein misfolding and aggregation. Through these investigations, the potential therapeutic applications of DNAJC5B targeting in neurodegenerative diseases are being explored, highlighting its significance in the field of molecular biology and medicine.
