Analytical Data
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Gene name
tTBK2
- Application
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Alternative Names
tTBK2；KIAA0847；Tau-tubulin kinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6IQ55
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Expression Region
18-287aa
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AA Sequence
KERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTF
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Molecular Weight
38.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBK1 (TANK-binding kinase 1) plays a crucial role in the innate immune response, particularly in antiviral defense and inflammation regulation. The TBK1 pathway is essential for the activation of interferon regulatory factors, which are critical for the production of type I interferons during viral infections. Mutations in the TBK1 gene have been implicated in various neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia, highlighting its significance in cellular processes beyond immune response. Research into the recombinant TBK1 protein (rTBK1) enables scientists to investigate its structure, function, and regulatory mechanisms in detail. By expressing rTBK1 in a suitable system, researchers can elucidate its kinase activity, identify potential substrates, and explore its interactions with other proteins involved in signaling pathways. This protein can also serve as a valuable tool for drug discovery and therapeutic interventions targeting TBK1-related disorders. Overall, the study of rTBK1 contributes to a deeper understanding of its multifaceted roles in health and disease, providing insights that may lead to novel therapeutic strategies.
