Analytical Data
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基因名
VPS52
- Application
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别名
VPS52; SACM2LVacuolar Protein sorting-associated Protein 52 homolog; SAC2 suppressor of actin mutations 2-like Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N1B4
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表达区间
2-723 aa
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氨基酸序列
AAAATMAAA ARELVLRAGT SDMEEEEGPL AGGPGLQEPL QLGELDITSD EFILDEVDVH IQANLEDELV KEALKTGVDL RHYSKQVELE LQQIEQKSIR DYIQESENIA SLHNQITACD AVLERMEQML GAFQSDLSSI SSEIRTLQEQ SGAMNIRLRN RQAVRGKLGE LVDGLVVPSA LVTAILEAPV TEPRFLEQLQ ELDAKAAAVR EQEARGTAAC ADVRGVLDRL RVKAVTKIRE FILQKIYSFR KPMTNYQIPQ TALLKYRFFY QFLLGNERAT AKEIRDEYVE TLSKIYLSYY RSYLGRLMKV QYEEVAEKDD LMGVEDTAKK GFFSKPSLRS RNTIFTLGTR GSVISPTELE APILVPHTAQ RGEQRYPFEA LFRSQHYALL DNSCREYLFI CEFFVVSGPA AHDLFHAVMG RTLSMTLKHL DSYLADCYDA IAVFLCIHIV LRFRNIAAKR DVPALDRYWE QVLALLWPRF ELILEMNVQS VRSTDPQRLG GLDTRPHYIT RRYAEFSSAL VSINQTIPNE RTMQLLGQLQ VEVENFVLRV AAEFSSRKEQ LVFLINNYDM MLGVLMERAA DDSKEVESFQ QLLNARTQEF IEELLSPPFG GLVAFVKEAE ALIERGQAER LRGEEARVTQ LIRGFGSSWK SSVESLSQDV MRSFTNFRNG TSIIQGALTQ LIQLYHRFHR VLSQPQLRAL PARAELINIH HLMVELKKHK PNF
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分子量
82.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The VPS52 protein, a critical component of the TSET (Transporter associated with the ER and Golgi) complex, plays an essential role in vesicular trafficking and protein sorting within eukaryotic cells. Its function is particularly significant in the context of endosomal and Golgi apparatus interactions, influencing the transport and processing of various proteins. Research into VPS52 has gained momentum due to its implications in cellular communication, metabolic regulation, and the pathogenesis of various diseases. Abnormalities in VPS52 activity or expression can lead to impaired cellular transport mechanisms, contributing to conditions such as cancer and neurodegenerative disorders. Recent studies utilizing advanced molecular biology techniques, including CRISPR-Cas9 and RNA sequencing, have shed light on VPS52's structure-function relationship and its regulatory pathways. As the understanding of VPS52 deepens, it becomes increasingly evident that targeting this protein could offer new therapeutic avenues for diseases linked to dysfunctional protein transport. Ongoing research focuses on elucidating the specific roles of VPS52 in different cellular contexts, its interactions with other proteins in the TSET complex, and the impact of its dysregulation on human health, presenting promising prospects for future studies in cell biology and targeted therapies.
