Analytical Data
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Gene name
DNAJC11
- Application
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Alternative Names
dJ126A5.1; DJC11_HUMAN; DnaJ (Hsp40) homolog; subfamily C; member 11; DnaJ homolog subfamily C member 11; DNAJC11; E030019A03Rik; FLJ10737; Novel DnaJ domain containing protein; RP1-126A5.3; RP23-460D14.2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NVH1
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Expression Region
1-507aa
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AA Sequence
MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDATDLFDRYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSVGVPQGVSLKVKELEKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMVLDSEALRIPKQSHRIDTDG
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Molecular Weight
83.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNAJC11, a member of the DnaJ/Hsp40 family of chaperone proteins, plays a crucial role in the regulation of protein folding and maintenance of cellular homeostasis. This protein is primarily localized in the endoplasmic reticulum (ER) and is known to interact with various substrates, assisting in the prevention of protein misfolding and aggregation. Given its significant involvement in cellular stress responses, particularly under conditions that lead to the accumulation of unfolded proteins, DNAJC11 has garnered attention in the context of diseases related to protein misfolding, such as neurodegenerative disorders and certain cancers. The study of DNAJC11 recombinant protein is essential to understand the specific mechanisms by which it contributes to ER function and overall cellular health. Researchers are exploring its potential as a therapeutic target, aiming to manipulate its activity to enhance cellular resilience against stress-induced damage. Additionally, understanding the structural and functional properties of DNAJC11 through recombinant expression systems can provide insights into its interaction with other molecular chaperones and client proteins, thereby elucidating its role in the broader network of protein quality control within the cell. Thus, the investigation of DNAJC11 not only enhances our fundamental knowledge of molecular chaperones but also opens avenues for innovative therapeutic strategies aimed at mitigating the effects of protein misfolding diseases.
