Analytical Data
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Gene name
STRA8
- Application
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Alternative Names
Stimulated by retinoic acid 8; stimulated by retinoic acid 8 homolog; Stimulated by retinoic acid Gene 8; stimulated by retinoic acid gene 8 homolog; Stimulated by retinoic acid gene 8 protein homolog; STRA 8; STRA8; STRA8_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z7C7
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Expression Region
1-330 aa
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AA Sequence
MGKIDVDKIL FFNQEIRLWQ LIMATPEENS NPHDRATPQL PAQLQELEHR VARRRLSQAR HRATLAALFN NLRKTVYSQS DLIASKWQVL NKAKSHIPEL EQTLDNLLKL KASFNLEDGH ASSLEEVKKE YASMYSGNDS FPQNGSSPWY LNFYKQTMDL LTGSGIITPQ EAALPIVSAA ISHLWQNLSE ERKASLRQAW AQKHRGPATL AEACREPACA EGSVKDSGVD SQGASCSLVS TPEEILFEDA FDVASFLDKS EVPSTSSSSS VLASCNPENP EEKFQLYMQI INFFKGLSCA NTQVKQEASF PVDEEMIMLQ CTETFDDEDL
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Molecular Weight
36.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STRA8 (Stimulated by Retinoic Acid 8) is a crucial protein involved in the regulation of spermatogenesis and germ cell differentiation in male mammals. Its research background is rooted in the understanding of how retinoic acid signaling influences germ cell development, specifically the transition from spermatogonial stem cells to differentiated sperm cells. STRA8 expression is tightly regulated by retinoic acid, which initiates meiosis in male germ cells and plays a pivotal role in fertility. Given the significance of STRA8 in reproductive biology, researchers have focused on its molecular mechanisms, expression patterns, and potential applications in treating infertility and understanding germ cell tumors. The study of STRA8 also extends to its evolutionarily conserved functions across species, highlighting its importance in developmental biology and reproductive health. Investigating STRA8's interactions with other signaling pathways and transcription factors provides insights into the complex regulatory networks that govern germ cell fate and male fertility. As the field progresses, STRA8 remains a critical subject for understanding male reproductive disorders and developing targeted therapies, emphasizing the need for continued research into its biological functions and clinical implications.
