Analytical Data
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基因名
VPS16
- Application
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别名
HGNC:14584; hVPS16; mVPS16; RP11 12M19.2; Vacuolar Protein sorting 16 (yeast); Vacuolar Protein sorting 16 (Yeast); isoform CRA_a; Vacuolar Protein sorting 16; Vacuolar Protein sorting 16 homolog (S. cerevisiae); vacuolar Protein sorting associated Protein 16 homolog; Vacuolar Protein sorting Protein 16; Vacuolar Protein sorting-associated Protein 16 homolog; VPS16; VPS16_HUMAN; VPS16A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H269
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表达区间
1-839 aa
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氨基酸序列
MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELRDCLVAAAPYGGPIALLRNPWRKEKAASVRPVLDIYSASGMPLASLLWKSGPVVSLGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAHRFTLSANVGDLKLRRMPEVPGLQSAPSCWTVLCQDRVAHILLAVGPDLYLLDHAACSAVTPPGLAPGVSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWCSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPAASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLTQAVQQCIEAAGHEHQPDMQKSLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAVRDYHIGIPLTYSQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNEAELSLVLSHCTGATDGATADKIQRARAQAQKK
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分子量
121.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS16, or Vacuolar Protein Sorting 16, is a significant component of the multi-subunit complex involved in cellular trafficking and endosomal sorting processes, particularly in the context of the endosomal-lysosomal pathway. Understanding VPS16 is pivotal for elucidating the mechanisms behind intracellular protein distribution and degradation. This protein plays a critical role in the assembly and function of the Class C core complex, which is essential for the transport of proteins to their final destinations within the cell. Research has shown that VPS16 is implicated in various physiological processes, including autophagy, membrane trafficking, and receptor recycling. Dysregulation of VPS16 and its associated pathways has been linked to several pathological conditions, including neurodegenerative diseases and cancer. Due to its importance in cellular homeostasis, VPS16 has become a focus of investigation in cell biology, with studies aimed at deciphering its structural characteristics, functional interactions, and regulatory mechanisms. Advances in techniques such as cryo-electron microscopy and molecular modeling are providing deeper insights into the structural dynamics of VPS16, paving the way for potential therapeutic targets to correct trafficking defects associated with its dysfunction. The growing body of research surrounding VPS16 thus highlights not only its fundamental role in cellular processes but also its potential implications in understanding and treating diseases linked to misregulated protein sorting and trafficking.
