Analytical Data
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Gene name
DNAH6
- Application
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Alternative Names
DNAH6; DNAHC6; DNHL1; HL2; KIAA1697Dynein heavy chain 6; axonemal; Axonemal beta dynein heavy chain 6; Ciliary dynein heavy chain 6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C0G6
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Expression Region
1-408aa
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AA Sequence
MTYTEQASKRHYCMRLTCFIRLNDYLIENTMHILTVNAVNSLLNHLTDKLKRTPSADVIQKWITEEKPEVPDKKGTLMVEKQEEDESLIPMFLTELMLTVQSLLFEPSLEDFLDGILGAVNHCQNTVLSVPNLVPDSYFDAFTSPYINNKLEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAAFESARIYAATFEKFQIFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLLLIDTRLLREKLIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLFLDEIQERIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRESSIKQFCVHLGSDLEELNNEVNEVKLQAQVS
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Molecular Weight
44.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNAH6 (Dynein Axonemal Heavy Chain 6) is a crucial component of the dynein motor protein complex, playing a vital role in ciliary and flagellar movement. This protein is essential for the proper functioning of motile cilia, which are cellular structures that facilitate movement in various organisms, including humans. Mutations in the DNAH6 gene have been linked to respiratory diseases and other ciliopathies, highlighting its significance in maintaining ciliary motility and overall cellular function. Research into DNAH6 recombinant protein has gained momentum, as it provides valuable insights into the molecular mechanisms governing ciliary dynamics. By producing and studying DNAH6 in a recombinant form, scientists can investigate its structural properties, interactions with other proteins, and functional roles in ciliary assembly and movement. Understanding the behavior of DNAH6 is not only critical for elucidating the pathological mechanisms underlying ciliary dysfunctions but also for exploring potential therapeutic targets for related diseases. Furthermore, the generation of specific antibodies and the development of high-throughput screening methods using recombinant DNAH6 can pave the way for innovative research approaches in the field of cell biology and genetics. This body of work is instrumental in advancing our comprehension of ciliary function and its implications for human health, particularly in the context of ciliary-related disorders.
