Analytical Data
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基因名
UGCG
- Application
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别名
UGCG；Ceramide glucosyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16739
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表达区间
1-394aa
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氨基酸序列
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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分子量
47.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UGCG (Ubiquitous Glucosylceramidase) is an enzyme that plays a crucial role in sphingolipid metabolism by catalyzing the conversion of glucosylceramide to ceramide and glucose. Research on UGCG has gained significant attention due to its implications in various pathological conditions, including Gaucher disease, cancer, and neurodegenerative disorders. The dysregulation of UGCG activity has been linked to the accumulation of glucosylceramide, which can lead to cellular toxicity and inflammation. Understanding the structure and function of UGCG, as well as the mechanisms regulating its activity, is essential for developing therapeutic strategies. Recombination of UGCG protein allows for the study of its biochemical properties and interactions in vitro, providing insights into its role in disease processes. Moreover, engineering UGCG through recombinant DNA technology holds the potential for creating novel therapies that can target glucosylceramide accumulation or modulate sphingolipid signaling pathways. Therefore, ongoing research in UGCG protein recombination aims to elucidate its biological significance and therapeutic potential, ultimately contributing to advancements in treating related metabolic disorders and enhancing our understanding of lipid metabolism.
