Analytical Data
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基因名
VPS11
- Application
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别名
END1; HGNC:14583; hVPS11; PEP5; PP3476; RING finger Protein 108; RNF108; Vacuolar Protein sorting 11 (yeast homolog); Vacuolar Protein sorting 11 (yeast); Vacuolar Protein sorting 11 homolog (S. cerevisiae); Vacuolar Protein sorting 11 homolog; Vacuolar Protein sorting associated Protein 11 homolog; Vacuolar Protein sorting Protein 11; Vacuolar Protein sorting-associated Protein 11 homolog; vps11; VPS11_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H270
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表达区间
1-331 aa
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氨基酸序列
MSEVQPDSPQGIYDTLLELRLQNWAHEKDPQVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVISVCERHGEQDPSLWEQALSYFARKEEDCKEYVAAVLKHIENKNLMPPLLVVQTLAHNSTATLSVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLRCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTSSLEAGLQRDLLMHSRRGT
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS11 is a crucial component of the vacuolar protein sorting (VPS) pathway, playing a significant role in vesicular trafficking and protein sorting within eukaryotic cells. The VPS pathway is essential for the proper localization of proteins to vacuoles or lysosomes, which are vital for cellular homeostasis and organelle function. Dysregulation of VPS proteins, including VPS11, has been implicated in various human diseases, particularly neurodegenerative disorders and cancers. The study of VPS11 as a recombinant protein has gained attention due to its potential impact on understanding intracellular transport mechanisms and its implications in disease pathology. By expressing VPS11 as a recombinant protein, researchers aim to investigate its structural characteristics, functional roles in vesicle formation and fusion, and interactions with other VPS components, elucidating its involvement in the sorting process. Furthermore, understanding the mechanisms governing VPS11 function can provide insights into developing therapeutic strategies for conditions resulting from VPS dysfunction. This research not only enhances the fundamental knowledge of cellular trafficking but also opens avenues for pharmacological interventions targeting VPS-related pathologies. Overall, VPS11 represents a significant focus in cell biology, highlighting the intricate and critical nature of protein sorting and trafficking within cells.
