Analytical Data
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Gene name
TIAM1
- Application
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Alternative Names
TIAM1；Rho guanine nucleotide exchange factor TIAM1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13009
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TIAM1, or T-lymphoma invasion and metastasis 1, is a critical guanine nucleotide exchange factor (GEF) that primarily activates Rac1, a member of the Rho family of small GTPases. Its role in regulating actin cytoskeleton dynamics makes it essential for processes such as cell migration, adhesion, and proliferation. Abnormal expression and activity of TIAM1 have been implicated in various pathologies, particularly in cancer, where it contributes to tumor invasion and metastasis. Importantly, TIAM1 is also involved in neural development and synaptic plasticity, underscoring its significance in both oncological and neurobiological contexts. Research into TIAM1 recombinant proteins is crucial for unraveling its mechanistic roles in these processes. By studying the structure, function, and interactions of TIAM1, scientists aim to understand how its dysregulation leads to disease. Additionally, recombinant TIAM1 proteins can serve as valuable tools in biochemical assays, allowing for the exploration of its potential as a therapeutic target. The development of functional assays utilizing TIAM1 recombinant proteins holds promise for identifying new strategies to inhibit its pathogenic effects in cancer and neurodegenerative diseases, ultimately contributing to therapeutic advancements.
