Analytical Data
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Gene name
DMRTC1
- Application
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Alternative Names
DMRTC1;; DMRTC1BDoublesex- and mab-3-related transcription factor C1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5HYR2
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Expression Region
1-192aa
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AA Sequence
MAAPPKAPIRVRNLTIRAGALTGKENNMLQPETHIFTAPEEGSSQGALLLGQAPEPLSLPCTPVTLEQQLVSPSGDPHRAPALPSICSTLILQPCATLDPLLLQPQVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGDKGFQPPSPSLRPRPASSISLPIGHLGCISLLS
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Molecular Weight
21.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DMRTC1, a member of the DMRT (Doublesex and Mab-3 related transcription factor) gene family, has gained attention in recent years for its critical role in sexual development and differentiation across various species. Initially identified in Drosophila, the DMRT proteins are known to regulate sex-specific traits and developmental pathways, which has implications for understanding sexual dimorphism. In vertebrates, DMRTC1 has been linked to the regulation of testis development and spermatogenesis, making it a candidate for studying male fertility and associated disorders. Research indicates that mutations or dysregulation of DMRTC1 can lead to abnormalities in gonadal development and function. Additionally, its expression patterns in different tissues suggest a broader role in development beyond reproductive organs. Investigations into the molecular mechanisms underlying DMRTC1 function and its interactions with other genes are crucial for elucidating its role in both normal biology and pathological conditions, such as intersex disorders and infertility. Understanding the pathways and targets of DMRTC1 could provide insights into novel therapeutic strategies for reproductive health issues and enhance our knowledge of evolutionary biology regarding sex differentiation. As research on DMRTC1 advances, it holds potential for significant contributions to the fields of developmental biology, genetics, and reproductive medicine.
