Analytical Data
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Gene name
TXK
- Application
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Alternative Names
TXK；PTK4；RLK；；Tyrosine-Protein kinase TXK
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P42681
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Expression Region
1-527aa
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AA Sequence
MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH LGSYTISVFM GARRSTEAAI KHYQIKKNDS GQWYVAERHA FQSIPELIWY HQHNAAGLMT RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS EGFRLYRPHL APMSIYEVMY SCWHEKPEGR PTFAELLRAV TEIAETW
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXK, a member of the TEC family of non-receptor protein tyrosine kinases, plays a significant role in various cellular processes, particularly in immune cell signaling and activation. It is primarily expressed in T cells, where it regulates signaling pathways essential for T cell development, differentiation, and function. Research has indicated that TXK is involved in the immune response against infections and tumors, making it a potential target for therapeutic interventions. Recent studies have focused on the structural characteristics and functional mechanisms of TXK, revealing insights into its enzymatic activity and interaction with other signaling molecules. Additionally, the abnormal expression or mutation of TXK has been linked to certain hematological malignancies and autoimmune diseases, prompting further investigation into its role as a biomarker and therapeutic target. Understanding the detailed mechanisms of TXK and its interactions within the signaling networks may provide new avenues for developing treatments for diseases associated with dysregulated immune responses. This has led to an increasing interest in the design of TXK inhibitors and the exploration of its therapeutic potential in modulating immune responses for better clinical outcomes. As research progresses, TXK continues to emerge as a critical player in the field of immunology and cancer therapy.
