Analytical Data
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基因名
TXK
- Application
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别名
TXK；PTK4；RLK；；Tyrosine-Protein kinase TXK
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42681
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表达区间
1-527aa
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氨基酸序列
MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH LGSYTISVFM GARRSTEAAI KHYQIKKNDS GQWYVAERHA FQSIPELIWY HQHNAAGLMT RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS EGFRLYRPHL APMSIYEVMY SCWHEKPEGR PTFAELLRAV TEIAETW
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXK, a member of the TEC family of non-receptor protein tyrosine kinases, plays a significant role in various cellular processes, particularly in immune cell signaling and activation. It is primarily expressed in T cells, where it regulates signaling pathways essential for T cell development, differentiation, and function. Research has indicated that TXK is involved in the immune response against infections and tumors, making it a potential target for therapeutic interventions. Recent studies have focused on the structural characteristics and functional mechanisms of TXK, revealing insights into its enzymatic activity and interaction with other signaling molecules. Additionally, the abnormal expression or mutation of TXK has been linked to certain hematological malignancies and autoimmune diseases, prompting further investigation into its role as a biomarker and therapeutic target. Understanding the detailed mechanisms of TXK and its interactions within the signaling networks may provide new avenues for developing treatments for diseases associated with dysregulated immune responses. This has led to an increasing interest in the design of TXK inhibitors and the exploration of its therapeutic potential in modulating immune responses for better clinical outcomes. As research progresses, TXK continues to emerge as a critical player in the field of immunology and cancer therapy.
