Analytical Data
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Gene name
DMC1
- Application
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Alternative Names
Disrupted meiotic cDNA 1 homolog ; Disrupted meiotic cDNA 1; yeast; homolog of; dJ199H16.1; DMC 1; DMC1; DMC1 dosage suppressor of mck1 homolog; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast); DMC1 homologue
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14565
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Expression Region
1-340aa
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AA Sequence
MKEDQVVAEE PGFQDEEESL FQDIDLLQKH GINVADIKKL KSVGICTIKG IQMTTRRALC NVKGLSEAKV DKIKEAANKL IEPGFLTAFE YSEKRKMVFH ITTGSQEFDK LLGGGIESMA ITEAFGEFRT GKTQLSHTLC VTAQLPGAGG YPGGKIIFID TENTFRPDRL RDIADRFNVD HDAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
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Molecular Weight
37.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of DMC1 recombinase, a key protein involved in the process of homologous recombination during meiosis, has garnered significant attention due to its critical role in genetic diversity and stability. DMC1, a member of the Rad51 protein family, is essential for the repair of DNA double-strand breaks, which are a normal occurrence during meiosis. As organisms undergo sexual reproduction, DMC1 facilitates the pairing of homologous chromosomes, allowing for accurate segregation and the exchange of genetic material. Deficiencies or mutations in the DMC1 gene can lead to reproductive issues, including infertility and an increased risk of chromosomal abnormalities. Research into DMC1 has expanded to explore its interactions with other proteins, its regulatory mechanisms, and its evolutionary conservation across species. Studies utilizing model organisms, such as yeast and mice, have revealed the nuanced dynamics of DMC1 function in meiotic processes. Furthermore, understanding DMC1’s role opens avenues for investigating its potential implications in cancer biology, as improper recombination can lead to genomic instability. The ongoing research aims to elucidate the precise mechanisms that govern DMC1 activity and its broader biological significance, thereby contributing to the comprehension of reproductive health and genetic inheritance. Consequently, the exploration of DMC1 recombinase is positioned as a pivotal area of genetic and molecular biology research, with potential applications in addressing fertility issues and enhancing our understanding of genetic diseases.
